Article ID Journal Published Year Pages File Type
1997982 Molecular Cell 2007 4 Pages PDF
Abstract

Our view of DNA replication has been of two coupled DNA polymerases anchored to the replication fork helicase in a “replisome” complex, synthesizing leading and lagging strands simultaneously. New evidence suggests that three DNA polymerases can be accommodated into the replisome and that polymerases and repair factors are dynamically recruited and engaged without dismantling of the replisome.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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