| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1998392 | Molecular Genetics and Metabolism | 2012 | 7 Pages |
Abstract
⺠F-GlcNAc and rhodamine B inhibit CS/DS and KS GAG synthesis in bovine cartilage. ⺠Inhibitors decreased GAG synthesis in chondrocyte monolayer and cartilage chip explant culture. ⺠F-GlcNAc decreased GAG chain size whereas rhodamine B decreased amount of GAG chains. ⺠Both inhibitors decreased the amount of CS/DS and KS GAG equally. ⺠Rhodamine B and F-GlcNAc have different mechanisms of action in reducing GAG synthesis.
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Authors
Ainslie L.K. Derrick-Roberts, Wanda Marais, Sharon Byers,