Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1998437 | Molecular Genetics and Metabolism | 2011 | 5 Pages |
Abstract
The small, dense LDL phenotype is associated with an increased cardiovascular disease risk. A genome-wide scan performed on 236 nuclear families of the Quebec Family Study (QFS) revealed a quantitative trait locus affecting LDL peak particle diameter (LDL-PPD) and density on the 1p31 region. This region contains the low-density lipoprotein receptor-related protein 8 (LRP8) gene. LRP8, a receptor for apolipoprotein (apo) E, modulates apoE levels, thus contributing to plasma cholesterol and triglyceride (TG) concentrations. We investigate the effects of LRP8 polymorphisms on LDL-PPD, on the relative proportion of small LDL (<Â 255Â Ã
) and the absolute concentration of cholesterol among the small LDL particles. LRP8 rs5174 was associated with LDL-PPD and estimated cholesterol concentrations in the small LDL particles adjusted for the effects of age and sex (p = 0.008, p = 0.04, respectively). LRP8 rs3820198 was associated with total and LDL-cholesterol levels as well as with apoB concentrations adjusted for the effects of age and sex (p = 0.005, p = 0.004 and p = 0.01, respectively) but not with LDL size-related variables. These results suggest that LRP8 gene polymorphisms influence plasma cholesterol levels as well as size and composition of LDL particles.
Keywords
QTLSmall LDLVLDLCHDApoER2HDL-CLDL-CLRP8PAGGEHDLQFShigh-density lipoproteinapoapolipoproteinpolyacrylamide gradient gel electrophoresisGene variantscoronary heart diseasebody mass indexBMIquantitative trait locushigh-density lipoprotein cholesterolvery low density lipoproteinLow-density lipoproteinLDLPositional candidateSingle nucleotide polymorphismSNPLow-density lipoprotein cholesterolApolipoprotein E receptor 2
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Authors
G. Dolley, B. Lamarche, J.P. Després, C. Bouchard, L. Pérusse, M.C. Vohl,