| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1999879 | Molecular Genetics and Metabolism | 2006 | 4 Pages |
Abstract
We investigated whether succinate semialdehyde dehydrogenase deficiency alters γ-hydroxybutyric acid (GHB) receptor characteristics due to elevation of GHB levels in the mouse brain. The membrane homogenate binding and quantitative autoradiography using [3H]NCS-382 revealed no significant changes in the affinity (Kd), receptor density (Bmax), or displacement potency (IC50) in various brain regions of Aldh5a1−/− vs. Aldh5a1+/+ mice.
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Authors
Ashok K. Mehta, Georgianna G. Gould, Maneesh Gupta, Lawrence P. Carter, K. Michael Gibson, Maharaj K. Ticku,