Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2000081 | Molecular Genetics and Metabolism | 2007 | 4 Pages |
Abstract
Increased homocysteine concentrations in CBS gene mutation carriers are associated with reduced concentrations of folic acid and vitamin B12 in blood. In view of the adverse effects of mild hyperhomocysteinemia, routine testing of vitamin status in parents of homocystinuria patients may be warranted. The causal relationship and pathophysiological consequences are uncertain; it is likely that CBS gene mutation carriers need higher doses of dietary vitamins.
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Authors
Mahmoud F. Elsaid, Abdulbari Bener, Martin Lindner, Mahmoud Alzyoud, Noora Shahbek, Mohammed O. Abdelrahman, Ghassan Abdoh, Mohammed S. Bessisso, Johannes Zschocke, Georg F. Hoffmann,