Nitric oxide - A versatile key player in cochlear function and hearing disorders

Article ID	Journal	Published Year	Pages	File Type
2001368	Nitric Oxide	2012	11 Pages	PDF

Abstract

âº Nitric oxide is widely involved in inner ear pathophysiology. âº Nitric oxide regulates the gap-junction-systems, blood vessels and synaptic areas. âº The role of NO in different cochlear cell types is discussed. âº A correlation between increased NO-production and hearing loss is described. âº Ascorbic acid, dexamethasone and doxycycline reveal cytoprotection in the inner ear.

Keywords

tetrahydrobiopterin OHC iNOS NOS nNOS DAF TLR-4 NADPH BH4 FMN flavin adenine dinucleotide RNS N-methyl-d-aspartate SPL NG-nitro-l-arginine methyl ester L-NMMA NMDA eNOS AMPA Neural nitric oxide synthase NG-monomethyl-l-arginine monoacetate LPS ABR 4,5-diaminofluorescein diacetate l-NAME ROS Adenosine Triphosphate ATP Ascorbic acid gap junctions Hearing loss α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid γ-aminobutyric acid IHC FAD Gentamicin Cytoprotection decibel Hour Sound pressure level outer hair cell Inner hair cell inducible nitric oxide synthase endothelial nitric oxide synthase flavin mononucleotide lipopolysaccharide Meniere’s Disease Nitric oxide nitric oxide synthase nicotinamide adenine dinucleotide phosphate auditory brainstem response endocochlear potential high performance liquid chromatography HPLC GABA Inner ear reactive nitrogen species Reactive oxygen species Toll-like receptor 4 glucocorticoid receptor