Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2002099 | Nitric Oxide | 2007 | 4 Pages |
Abstract
The present article was aimed at determining the alveolar-capillary PO2 difference (ÎPAc¯O2) during exercise. The working hypothesis was that values of the pulmonary NO diffusing capacity can be used to calculate ÎPAc¯O2 data on the basis of well-known laws of pulmonary gas exchange. For this purpose, we analysed the pertinent data of three studies performed on 35 healthy, non-athletic non-smokers of similar age at seven different exercise intensities. Calculated mean values of alveolar-capillary PO2 difference aggravated from ÎPAc¯O2=2mmHg at rest to ÎPAc¯O2=18mmHg at a performance capacity amounting to 90% of the maximum level. Regression analysis revealed ÎPAc¯O2=0.31·(VËO2/VËO2max)-0.0012·(VËO2/VËO2max)2 at a very high significance level (n = 7, r = 0.999, P < 0.0000082). Due to the non-linear increase of ÎPAc¯O2 with inclining O2 consumption, our model analysis confirms the opinion that pulmonary diffusion decreasingly determines maximal aerobic power.
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Authors
H. Heller, K.-D. Schuster,