Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation

► Application of senktide, a NK3R agonist, modified chromatin and gene expression. ► Senktide (1 or 10 nM) increased histone acetylation and gene expression. ► Increased gene expression was largely prevented by pretreatment with HAT inhibitors. ► Senktide (100 nM) decreased acetylation and gene expression, and compacted chromatin.