| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2006262 | Peptides | 2012 | 9 Pages |
Abstract
⺠Bilateral renal ischemia/reperfusion (IR) induced kidney injury in mice. ⺠IR activated Toll-like receptors (TLRs). ⺠TLRs induced inflammatory cytokine production. ⺠Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) modulated TLRs. ⺠PACAP38 protected kidney even when treatment was started 24 h after IR.
Keywords
NF-κBIRFFADDTLRPACAPMCP-1IFN-γKIM-1H&EMAPKTRIFGene arraysacute kidney injuryperiodic acid-Schiffischemia/reperfusionInnate immunityinterferon γinterleukinTerminal deoxynucleotidyl transferase dUTP nick end labelingtumor necrosis factor αTUNELToll-like receptorFas-associated death domainApoptosisCytokinesinterferon regulatory factorTNF-αnuclear factor κBKidney injury molecule 1PASHematoxylin and Eosinmitogen-activated protein kinasepituitary adenylate cyclase-activating polypeptidePeptidesToll-like receptors
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Authors
Altaf-M. Khan, Min Li, Solange Abdulnour-Nakhoul, Jerome L. Maderdrut, Eric E. Simon, Vecihi Batuman,