Article ID Journal Published Year Pages File Type
2006328 Peptides 2012 7 Pages PDF
Abstract
► IMD1-53 attenuated the myocardial injury by inhibiting MDA content and LDH activity, elevating the Mn-SOD and CAT activity and decreasing the expression of gp91phox and p47phox. ► IMD1-53 attenuated H2O2-induced cardiomyocyte apoptosis in vitro. ► IMD1-53 activated the ERK1/2 signaling pathway. ► IMD1-53 may improve the oxidative stress injury by enhancing ERK phosphorylation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion
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