Article ID Journal Published Year Pages File Type
2006346 Peptides 2011 10 Pages PDF
Abstract
► Selected ubiquitin-derived peptides were tested for their immunomodulatory potency. ► Peptide VKTLTGKTI possessed the highest immunosuppressive potency in vitro. ► VKTLTGKTI was also active in allograft survival experiments in mice. ► Basing on ubiquitin crystal structure we designed analogs of selected peptides. ► Immunomodulatory activity of synthesized analogs (cyclic and bivalent) was tested.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
, , , , , ,