Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2006346 | Peptides | 2011 | 10 Pages |
Abstract
⺠Selected ubiquitin-derived peptides were tested for their immunomodulatory potency. ⺠Peptide VKTLTGKTI possessed the highest immunosuppressive potency in vitro. ⺠VKTLTGKTI was also active in allograft survival experiments in mice. ⺠Basing on ubiquitin crystal structure we designed analogs of selected peptides. ⺠Immunomodulatory activity of synthesized analogs (cyclic and bivalent) was tested.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
PaweŠPasikowski, Tomasz Goździewicz, Piotr Stefanowicz, Jolanta Artym, MichaŠZimecki, Zbigniew Szewczuk,