Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2006371 | Peptides | 2010 | 6 Pages |
Abstract
ⶠArg-containing peptides (R6L2W3 and R6L2W3-d) were more toxic to human erythrocytes and mammalian cells as compared to Lys-containing peptides (K6L2W3 and K6L2W3-d). ⶠArg-containing peptides are slightly more hydrophobic than Lys-containing peptides. ⶠA little difference in the hydrophobicity of peptides affect their hemolytic activity and mammalian cell toxicity. ⶠLys-containing peptides penetrated the cell wall and cell membrane and accumulated inside the cells, whereas Arg-containing peptides did not penetrate but associated with the membranes. ⶠThe ultimate target site of action of Arg-containing peptides and Lys-containing peptides may be the membrane and the cytoplasm of Candida albicans, respectively.
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Authors
Yong Hai Nan, Sung Haeng Lee, Hak Jun Kim, Song Yub Shin,