Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors

▶ Non-specific binding of NPY, PYY and PP is typically in 6:2:1 ratio. ▶ This relates to acidic pairs with aspartate (2 in NPY, 1 in PYY, 0 in PP) and proline-13 in NPY. ▶ The above should also be important in agonist selectivity of Y receptor subtypes. ▶ The differences should also be important for partial agonism and cross-reactivity.