Article ID Journal Published Year Pages File Type
2006599 Peptides 2011 8 Pages PDF
Abstract
▶ Perfusion of angiotensin II into isolated beating atria decreased the ANP secretion. ▶ The suppression of ANP secretion by angiotensin II was more prominent in high-stretched beating atria. ▶ Angiotensin II-induced suppression of ANP secretion was blocked by AT1 receptor blocker. ▶ Losartan augmented stretch-induced ANP secretion. ▶ In renal hypertensive atria, the responses of ANP secretion to angiotensin II and losartan were accentuated because of upregulation of AT1 receptor.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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