| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2006671 | Peptides | 2011 | 4 Pages |
Preclinical and clinical studies suggest that whey proteins can reduce postprandial glucose levels and stimulate insulin release in healthy subjects and in subjects with type 2 diabetes by reducing dipeptidyl peptidase-4 (DPP-4) activity in the proximal bowel and hence increasing intact incretin levels. Our aim was to identify DPP-4 inhibitors among short peptides occurring in hydrolysates of β-lactoglobulin, the major whey protein found in the milk of ruminants. We proved that the bioactive peptide Ile-Pro-Ala can be regarded as a moderate DPP-4 inhibitor.
Research highlights► Whey proteins can reduce postprandial glucose levels and stimulate insulin release. ► Administration of whey protein was associated with higher levels of intact incretins. ► Dipeptidyl peptidase-4 (DPP-4) is the main enzyme responsible for incretin degradation. ► β-Lactoglobulin is the major whey protein found in the milk of cows and other ruminants. ► Ile-Pro-Ala (IPA) is a bioactive peptide generated by proteolysis of bovine β-lactoglobulin. ► Our results showed that IPA can be regarded as a moderate DPP-4 inhibitor.
