| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2006789 | Peptides | 2010 | 8 Pages |
Abstract
ⶠHuman RFRP-1 peptide (hRFRP-1) dramatically decreases contractility in isolated cardiac myocytes. ⶠThe structurally-related peptide 26RFa does not affect contractility in isolated cardiac myocytes. ⶠPertussis toxin did not affect the influence of hRFRP-1 on cardiac function in isolated cardiac myocytes suggesting the peptide activates PKC to impact contractility. ⶠHuman RFRP-1 decreases cardiac function in whole animal as well as in the isolated cardiac myocyte.
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Authors
R. Nichols, L.A. Demers, B.M. Larsen, D. Robinson, K. Converso, M.W. Russell, M.V. Westfall,