Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2007150 | Peptides | 2008 | 9 Pages |
Abstract
The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP). The active UT mediates pleiotropic effects through various signal transduction pathways, including coupling to G proteins and activating the mitogen-activated protein kinase pathway. Several highly conserved residues and motifs of class A GPCRs that are important for activity are found in UT. This review highlights some of the putative roles of these motifs in the binding, activation and desensitization of UT.
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Authors
Christophe D. Proulx, Brian J. Holleran, Pierre Lavigne, Emanuel Escher, GaƩtan Guillemette, Richard Leduc,