| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2007300 | Peptides | 2008 | 5 Pages |
Abstract
Enterostatin (APGPR) found in the gastrointestinal tract and brain is an anorectic pentapeptide. We found that APGPR inhibited morphine-induced analgesia after intracerebroventricular administration in mice at a dose of 10 nmol/mouse. The anti-analgesic effect of APGPR was inhibited by pretreatment with lorglumide and LY225910, antagonists for cholecystokinin 1 (CCK1) and cholecystokinin 2 (CCK2) receptors, respectively. The anti-analgesic effect of APGPR may be mediated by CCK release, since APGPR does not have affinity for CCK receptors.
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Authors
Yasuyuki Takenaka, Tomoko Shimano, Yuko Yamada, Mariko Yoshida, Kousaku Ohinata, Masaaki Yoshikawa,