Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2008058 | Peptides | 2006 | 8 Pages |
Abstract
Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.
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Authors
Susan Aja, Cassandra Ewing, Jennifer Lin, Jayson Hyun, Timothy H. Moran,