| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2008171 | Peptides | 2005 | 7 Pages |
Abstract
Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic a-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.
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Authors
Jacquelien J.G. Hillebrand, Martien J.H. Kas, Roger A.H. Adan,