Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2008195 | Peptides | 2005 | 9 Pages |
Abstract
Proopiomelanocortin (POMC) cDNAs were cloned and sequenced from brain extracts of two species of urodele amphibians: Amphiuma means and Necturus maculosus. Although the two species of urodele amphibians belong to separate families, and do not share a direct common ancestor, the level of primary sequence identity for the open reading of the POMC cDNAs was 90% at the amino acid level and 79% at the nucleotide level. It appears that the POMC gene in these urodele amphibians has been accumulating mutations at the amino acid level at a slower rate than the POMC gene in other sarcopterygian orders.
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Authors
Katarzyna Kozak, David Costantino, Stephanie Lecaude, Cristina Sollars, Phillip Danielson, Robert M. Dores,