Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2008222 | Peptides | 2006 | 9 Pages |
Abstract
We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (â605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (â11640A and â8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kwok Leung Ong, Louisa Y.F. Wong, Yu Bun Man, Raymond Y.H. Leung, You-Qiang Song, Karen S.L. Lam, Bernard M.Y. Cheung,