Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2008347 | Peptides | 2006 | 7 Pages |
Abstract
A pulsatile secretory pattern is assumed to improve hormonal efficiency. We examined the short-term time courses of circulating atrial (ANP) and brain natriuretic peptides (BNP) in patients with pulmonary hypertension (PH) and reduced renal efficiency of ANP-BNP, reflected by low natriuresis/ANP or BNP ratios. Compared to controls, we observed a persistence of ANP and BNP pulsatility in PH patients with a similar periodicity of 20Â min. Pulse amplitude increased proportionally to the rise in mean plasma level observed in patients (around 27%). In PH patients, the decrease in ANP-BNP renal efficiency is not attributable to a loss of the rhythmic pulsatility of these hormones.
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Authors
Anne Charloux, Ari Chaouat, Gabrielle Brandenberger, François Piquard, Emmanuel Weitzenblum, Bernard Geny,