Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2008700 | Peptides | 2005 | 5 Pages |
Abstract
The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, Leu13 psi(CH2NH)-Leu14] bombesin (6-14) (RC-3095) (0.2, 1.0 or 5.0Â mg/kg) 30Â min before exposure to an open field or an elevated plus maze. Habituation to the open field was tested in a retention trial carried out 24Â h after the first exposure to the open field. Rats given RC-3095 at the doses of 1.0 or 5.0Â mg/kg showed impaired habituation. Animals treated with 5.0Â mg/kg of RC-3095 spent significantly more time in the closed arms of the elevated plus maze. No effects of RC-3095 on locomotion or exploratory behavior were observed. The results implicate the GRPR in the regulation of non-emotional, non-associative memory as well as in anxiety.
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Authors
Márcio Rodrigo Martins, Adalisa Reinke, Samira S. Valvassori, Roberta A. Machado, João Quevedo, Gilberto Schwartsmann, Rafael Roesler,