Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2008766 | Peptides | 2005 | 5 Pages |
Abstract
LFampin 265–284, derived from bovine lactoferrin, has broad-spectrum antimicrobial activity against the yeast Candida albicans and several Gram-positive and Gram-negative bacteria. A glycine substitution scan was used to identify residues that are important for its candidacidal activity. Each single substitution of a positively charged residue led to considerable reduction in candidacidal activity, for each residue to a different extent. Substitution within the helix-facilitating N-terminal sequence DLIW had less severe effect; substitution of Ile and Trp led to a somewhat reduced potency. No substantial effects were found on the propensity to adopt a helical structure or to bind to C. albicans cells.
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Authors
Marieke I.A. van der Kraan, Christel van der Made, Kamran Nazmi, Wim van‘t Hof, Jasper Groenink, Enno C.I. Veerman, Jan G.M. Bolscher, Arie V. Nieuw Amerongen,