Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2012760 | Pharmacology Biochemistry and Behavior | 2015 | 9 Pages |
Abstract
The mismatch negativity (MMN) auditory event-related potential (ERP) has been extensively studied as a potential biomarker for abnormal auditory processing in schizophrenia (SZ), a population which exhibits abnormally high smoking rates. The relationship between nicotinic activation and cognition in SZ may be related to underlying nicotinic and NMDA receptor dysfunction within the disease. However, transient cognitive improvements via smoking in patients may also result from monoamine oxidase (MAO) inhibition, achieved through tobacco smoke. In 24 healthy non-smoking males, we investigated the separate and combined effects of nicotine and MAO-A inhibition via moclobemide (75Â mg) on the optimal-5 variation of the MMN paradigm. No significant drug effects were observed in our total sample, however, stratification of individuals into low (NÂ =Â 12) and high (NÂ =Â 12) baseline MMN amplitude groups revealed increases in duration MMN amplitude relative to placebo by nicotine, as well as moclobemide, but not after the combination of the two. Because previous research has shown there was no effect of monoamine modulation on MMN, this study shows an unexpected effect of moclobemide on duration MMN.
Keywords
MMNMNicSCID-NPVEOGMAO inhibitionHEOGNMDARMAO5-HTDHPGnAChRPCPATDDSMSchizophreniaγ-aminobutyric acidhorizontal electrooculogramvertical electrooculogramFIGSERPDiagnostic and Statistical Manual of Mental DisordersSerotoninbody mass indexBMIPhencyclidinecarbon monoxideSelective serotonin reuptake inhibitorSSRImonoamine oxidaseMoclobemidemismatch negativityNicotineEvent-related potentialAcute tryptophan depletionGABAN-methyl-d-aspartate receptornicotinic acetylcholine receptordopamine receptor 1dopamine receptor 2
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Authors
Dylan M. Smith, Derek Fisher, Pierre Blier, Vadim Ilivitsky, Verner Knott,