Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2013076 | Pharmacology Biochemistry and Behavior | 2012 | 7 Pages |
Abstract
⺠We examine whether a full cocaine dosing range can be studied in humans in one day. ⺠Procedures were well tolerated with no significant adverse events noted. ⺠Significant dose-dependent changes in measures of self-administration were found. ⺠Changes in cardiovascular and subjective outcomes were less robustly detected. ⺠The data support the safety, tolerability and validity of our single-day design.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
D. Matuskey, B. Pittman, J.I. Chen, J. Wanyiri, H. Nadim, P. Jatlow, R. Gueorguieva, M.N. Potenza, P.T. Morgan, Z. Bhagwagar, R.T. Malison,