| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2013232 | Pharmacology Biochemistry and Behavior | 2012 | 14 Pages |
Abstract
⺠Abnormal creatine metabolism is associated with major depressive disorders. ⺠We examined the efficacy of combined creatine and fluoxetine treatment in rats. ⺠Long-term creatine supplementation produced antidepressant effects in females only. ⺠Fluoxetine prolonged the benefit of creatine after repeating forced swim testing. ⺠The data support a relationship between creatine, serotonin, and ovarian hormones.
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Authors
Patricia J. Allen, Kristen E. D'Anci, Robin B. Kanarek, Perry F. Renshaw,