Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2013672 | Pharmacology Biochemistry and Behavior | 2009 | 6 Pages |
Abstract
Paroxetine is prescribed to treat depression, but it also produces nausea. The potential of animal models to detect nauseating, antidepressant-like, and rewarding/aversive effects of paroxetine were assessed. In Experiments 1 (spaced conditioning trials) and 3 (massed conditioning trials), a dose of 30Â mg/kg, but not lower doses (3 and 10Â mg/kg) of paroxetine produced conditioned gaping reactions (reflective of nausea) in the Taste Reactivity (TR) test. In Experiment 2, when administered 23.5, 5 and 1Â h prior to a 5Â min forced swim test (FST) a dose as low as 3Â mg/kg of paroxetine increased swimming and decreased immobility (reflective of antidepression) compared to controls. In Experiment 3, neither 10 nor 30Â mg/kg of paroxetine produced a conditioned floor preference/aversion, but both doses decreased activity during conditioning trials. These results suggest that paroxetine produced an antidepressant-like effect at a lower dose (3Â mg/kg) than that necessary to produce nausea (30Â mg/kg). The TR test may be beneficial for assessing the side effect of nausea in preclinical tests of new compounds.
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Authors
Katharine J. Tuerke, Francesco Leri, Linda A. Parker,