Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2013957 | Pharmacology Biochemistry and Behavior | 2007 | 8 Pages |
Abstract
The present study aimed to determine whether Nicotiflorin, a natural flavonoid extracted from coronal of Carthamus tinctorius, has a protective effect on cerebral multi-infarct dementia in rats. The multi-infarct dementia model rats were prepared by injecting man-made micro-thrombi into the right hemisphere. The administration groups were treated once daily with 30, 60 and 120Â mg/kg Nicotiflorin (i.g.) from 5Â days before ischemia operation to 3Â days after the operation for biochemical examination, 10Â days for Morris water maze study and morphological observations and 20Â days for eight-arm radial maze task. 2,3,5-triphenyltetrazolium chloride (TTC) staining showed that infarct volume of each Nicotiflorin administration group was much smaller than that of vehicle-treated multi-infarct dementia group, and hematoxylin and eosin (HE) staining showed that histopathological abnormalities of each Nicotiflorin group were also much lighter than that of vehicle-treated multi-infarct dementia group. Each Nicotiflorin group showed much better spatial memory performance in Morris water maze tests and eight-arm radial maze task compared with the vehicle-treated multi-infarct dementia group, significantly attenuated the elevation of lactic acid and malondialdehyde (MDA) contents and the decrease in lactate dehydrogenase (LDH), Na+K+ATPase, Ca2+Mg2+ATPase and superoxide dismutase (SOD) activity in the brain tissue which was composed of striatum, cortex and hippocampus of the ischemia hemisphere at day 3 after ischemia operation. These results suggest that Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.
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Authors
Jin-Ling Huang, Shou-Ting Fu, Yuan-Ying Jiang, Yong-Bing Cao, Mei-Li Guo, Yan Wang, Zheng Xu,