| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2014582 | Pharmacology Biochemistry and Behavior | 2006 | 6 Pages |
Abstract
The effect of home cage conspecifics' behavior on locomotor sensitization to amphetamine (AMP) or ethanol (ETOH) were investigated. Female mice were repeatedly treated with saline or AMP (2.0Â mg/kg for 13Â days - Experiment 1) or saline or ETOH (1.8Â g/kg for 21Â days - Experiment 2) in home cages where all the animals had the same treatment (homogeneous home cages - HOM-HC) or in home cages where half of the animals were drug-treated and half of them were saline-treated (heterogeneous home cages - HET-HC). Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. In both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can be modified by home cage conspecifics' behavior.
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Authors
N.P. Araujo, D.F. Fukushiro, J.L.S. Cunha, R. Levin, C.C. Chinen, R.C. Carvalho, I.C.P. Ribeiro, D.C. Gomes, V.C. AbÃlio, R.H. Silva, R. de A. Ribeiro, R. Frussa-Filho,