Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2018987 | Progress in Histochemistry and Cytochemistry | 2013 | 34 Pages |
Abstract
Besides its classical role in bone and calcium homeostasis, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has many non-classical effects; antiproliferative, anti-apoptotic and prodifferentiating effects of 1,25(OH)2D3 have been described in several tumour types in preclinical models. This review focuses on the insights gained in the elucidation of the role of 1,25(OH)2D3 in the normal thyroid and in the pathogenesis, progression and treatment of thyroid cancer, the most common endocrine malignancy. An increasing amount of observations points towards a role for impaired 1,25(OH)2D3-VDR signalling in the occurrence and progression of thyroid cancer, and a potential for structural analogues in the multimodal treatment of dedifferentiated iodine-resistant thyroid cancer. A role for vitamin D in thyroid-related autoimmunity is less convincing and needs further study. Altered 1,25(OH)2D3-VDR signalling does not influence normal thyroid development nor thyrocyte function, but does affect C-cell function, at least in rodents. If these findings also apply to humans deserves further study.
Keywords
VDRDUOXGPCRPendrinHDACiFGF23Retinoid X receptorSAHApTHATCTPOCYP24A1FNACCDKVDRETKIDTCRXRMTCTSHRPDTCCYP27B1CDKI25-OHD3Carcinoembryogenic antigenH202PTCPMCADBPPPITSHRT-PCRHDACtri-iodothyroninePDShptFTC1α-hydroxylase1α,25-dihydroxyvitamin D31,25(OH)2D324-hydroxylase25-hydroxyvitamin D3CeAG-protein coupled receptorH&ENiSHydrogen peroxideFollicular adenomaSuberoylanilide hydroxamic acidDITmittrhDifferentiated thyroid cancerThyroid peroxidasethyroxineThyroglobulindual oxidaseretinoblastomasodium iodide symporteranaplastic thyroid cancerFollicular thyroid cancerMedullary thyroid cancerpapillary thyroid cancerDendritic cellsfine needle aspiration cytologyvitamin D responsive elementplasma membrane calcium ATPaseVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)UltrasoundFibroblast growth factor-23Tyrosine kinase inhibitorhistone deacetylase inhibitorProton pump inhibitorcyclin-dependent kinase inhibitorknockoutWild type.haematoxylin and eosinThyrotropin releasing hormoneThyroid hormonethyroid stimulating hormoneHistone acetyltransferasehistone deacetylaseHypothalamic-pituitary-thyroidreverse transcriptase–polymerase chain reactionParathormoneVitamin D binding proteinHATCalcitonincyclin-dependent kinaseEstrogen receptorThyroid stimulating hormone receptorVitamin D receptor
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Authors
Isabelle Clinckspoor, Lieve Verlinden, Chantal Mathieu, Roger Bouillon, Annemieke Verstuyf, Brigitte Decallonne,