| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019440 | Prostaglandins & Other Lipid Mediators | 2015 | 7 Pages |
Abstract
A significant increase of exhaled 8-iso-PGE2 after inhalatory challenge with aspirin was selective and not present for the other isoprostane measured. This is a novel finding in AERD, suggesting that inhibition of cyclooxygenase may elicit 8-iso-PGE2 production in a specific mechanism, contributing to bronchoconstriction and systemic overproduction of cysteinyl leukotrienes.
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Authors
Lucyna Mastalerz, RafaÅ Januszek, Marek Kaszuba, Krzysztof Wójcik, Natalia Celejewska-Wójcik, Anna Gielicz, Hanna Plutecka, Krzysztof OleÅ, PaweÅ StrÄk, Marek Sanak,