Article ID Journal Published Year Pages File Type
2019468 Prostaglandins & Other Lipid Mediators 2015 4 Pages PDF
Abstract

•mPGES-1 is highly expressed in human colorectal cancer tissues.•Genetic deletion of mPGES-1 suppressed colon carcinogenesis in mouse models.•PGE2 receptors (EPs) are involved in colon carcinogenesis.•15-PGDH functions as a suppressor of colon carcinogenesis.•mPGES-1, EPs and 15-PGDH are attractive as novel drug targets for colorectal cancer.

Nonsteroidal anti-inflammatory drugs, especially selective cyclooxygenase-2 (COX-2) inhibitors, are among the most promising chemopreventive agents for colorectal cancer. However, recent clinical trials have indicated that these inhibitors pose a significantly increased cardiovascular risk. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) and mPGES-1-derived PGE2 have gained attention recently as alternative targets to COX-2 for colorectal cancer chemoprevention and chemotherapy. In this review, we summarize the current understanding of the roles of mPGES-1, a PGE2-inactivating enzyme (15-hydroxyprostagladin dehydrogenase), and PGE2 specific receptors (EPs) in colon carcinogenesis.

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