| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019472 | Prostaglandins & Other Lipid Mediators | 2015 | 13 Pages |
Abstract
- Transcriptional regulation of the PTGIR, the I Prostanoid receptor (IP) gene.
- Basal regulation by Sp1, PU.1 & Oct-1 and by C/EPBδ via the “core promoter” & URR.
- Switch of C/EPBδ to PU.1 “URR binding” & enhanced “core binding” upregulate the IP.
- Estrogen increases IP expression via an estrogen receptor(ER)α-dependent mechanism.
- Low serum-cholesterol increases IP expression via an SREBP1-dependent mechanism.
- Functional interaction of the IP with PDZK1 and with IKEPP within the vasculature.
Keywords
NHERFRCTPtgs2SREGIPPRRPDZphorbol 12-myristate 13-acetateRLUGPCRpKaSREBPERERBDHUVECNA+/H+ exchange regulatory factorhuman erythroleukemiarelative luciferase unitTBPPDZK1Y2HCOXRAB11TFIIDURRC/EBPC/EBP, CCAAT/enhancer binding proteinPMASite-directed mutagenesisTranscription initiationcyclooxygenasechromatin immunoprecipitationcoronary artery diseasecardiovascular diseasethromboxanestandard error of the meanPDZ domainCVDHuman umbilical vein endothelial cellhuman aortic smooth muscle cellEndothelial cellCADSterol response elementestrogen response elementcardiovascularyeast-two-hybridSEMSDMTAFCCAAT/enhancer binding proteinTATA-box binding proteinsterol response element binding proteincAMP-dependent protein kinase ASingle-nucleotide polymorphismSNPCHiPGeneHELEstrogen receptorProstacyclin receptorG protein-coupled receptor
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Authors
Helen M. Reid, B. Therese Kinsella,