| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019485 | Prostaglandins & Other Lipid Mediators | 2014 | 8 Pages |
Abstract
Epidemiological and pre-clinical studies support the anti-tumor effects of Ï-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of Ï-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which Ï-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The Ï-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived Ï-3-series lipid metabolites on angiogenesis, inflammation and cancer.
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Authors
Weicang Wang, Julia Zhu, Fei Lyu, Dipak Panigrahy, Katherine W. Ferrara, Bruce Hammock, Guodong Zhang,