Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2019503 | Prostaglandins & Other Lipid Mediators | 2016 | 10 Pages |
Abstract
Autophagy, the “self-digestion” mechanism of the cells, is an evolutionary conserved catabolic process that targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation, which plays a crucial role in development and disease. Cannabinoids are active compounds of Cannabis sativa and the most prevalent psychoactive substance is Î9-tetrahydrocannabinol (THC). Cannabinoid compounds can be divided in three types: the plant-derived natural products (phytocannabinoids), the cannabinoids produced endogenously (endocannabinoids) and the synthesized compounds (synthetic cannabinoids). Various studies reported a cannabinoid-induced autophagy mechanism in cancer and non-cancer cells. In this review we focus on the recent advances in the cannabinoid-induced autophagy and highlight the molecular mechanisms involved in these processes.
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Authors
Lia Costa, Cristina Amaral, Natércia Teixeira, Georgina Correia-da-Silva, Bruno M. Fonseca,