| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019570 | Prostaglandins & Other Lipid Mediators | 2013 | 8 Pages |
Abstract
•Total synthesis report of isoprostanes (IsoPs) and neuroprostanes (NeuroPs).•IsoPs and NeuroPs derived from a non-enzymatic peroxidation of PUFAs bound to phospholipids.•IsoPs are the most reliable biomarkers of lipid peroxidation in humans and animal models.•Several IsoPs have also been shown to be biologically active.
Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.
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Authors
Jean-Marie Galano, Emilie Mas, Anne Barden, Trevor A. Mori, Cinzia Signorini, Claudio De Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, Ralf Benndorf, Jérôme Roy, Jean-Yves Le Guennec, Camille Oger, Thierry Durand,