| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019586 | Prostaglandins & Other Lipid Mediators | 2013 | 10 Pages |
Abstract
⺠Prostanoids influence cytokine production on both antigen presenting cells and T cells to regulate the differentiation of naïve CD4+ T cells to Th1, Th2 and Th17 cell phenotypes. ⺠COXs and PGE2 generally suppressing Th1 differentiation and exacerbate Th2 and Th17 phenotypes. ⺠Targeting of cyclooxygenases and their eicosanoid products may represent a new approach for treatment of inflammatory diseases, tumors and autoimmune disorders.
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Authors
Hong Li, Matthew L. Edin, Artiom Gruzdev, Jennifer Cheng, J. Alyce Bradbury, Joan P. Graves, Laura M. DeGraff, Darryl C. Zeldin,