An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate

Under steady-state conditions, hematopoietic stem/progenitor cells (HSPCs) egress from bone marrow (BM) and enter peripheral blood (PB) where they circulate at low levels. Their number in PB, however, increases significantly in several stress situations related to infection, organ/tissue damage, or strenuous exercise. Pharmacologically mediated enforced egress of HSPCs from the BM microenvironment into PB is called “mobilization”, and this phenomenon has been exploited in hematological transplantology as a means to obtain HSPCs for hematopoietic reconstitution. In this review we will present the accumulated evidence that innate immunity, including the complement cascade and the granulocyte/monocyte lineage, and the PB plasma level of the bioactive lipid sphingosine-1-phosphate (S1P) together orchestrate this evolutionarily conserved mechanism that directs trafficking of HSPCs.

► Hematopoietic stem cells (HSCs) even in steady state conditions circulate in peripheral blood (PB) at low level. ► Pharmacologically mediated enforced egress of HSCs from the bone marrow microenvironment into PB is called “mobilization”. ► Innate immunity, complement cascade and the PB plasma level of the bioactive lipid sphingosine-1-phosphate (S1P) orchestrate this process.