| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019633 | Prostaglandins & Other Lipid Mediators | 2012 | 8 Pages |
Abstract
⺠EP2 receptor-deficient mice are protected from death from pneumococcal pneumonia. ⺠EP2 null mice have enhanced inflammatory responses to S. pneumoniae in the lungs. ⺠Alveolar macrophage phagocytosis of S. pneumoniae is suppressed by PGE2-EP2 signaling. ⺠PGE2 restricts pneumococcal killing by alveolar macrophages via the EP2 receptor. ⺠The EP2 receptor limits inflammatory mediator production by infected macrophages.
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Authors
David M. Aronoff, Ingrid L. Bergin, Casey Lewis, Deepti Goel, Edmund O'Brien, Marc Peters-Golden, Peter Mancuso,