Article ID Journal Published Year Pages File Type
2019639 Prostaglandins & Other Lipid Mediators 2012 5 Pages PDF
Abstract

There is a sufficient body of work documenting the distribution of 3-hydroxy oxylipins in microbes. However, there is limited information on the role of these compounds in microbial pathogenesis. When derived from mammalian cells, these compounds regulate patho-biological processes, thus an understanding of 3-hydroxy oxylipin function and metabolism could prove important in shedding light on how these compounds mediate cellular pathology and physiology. This could present 3-hydroxy oxylipin biosynthetic pathways as targets for drug development. In this minireview, we interrogate the relevant yeast and bacterial 3-hydroxy oxylipin literature in order to appreciate how these compounds may influence the inflammatory response leading to disease development.

► This paper reviews the available literature on microbial 3-hydroxy oxylipins. ► These molecules are reported to mediate cellular pathology and physiology. ► Biosynthetic pathways of these molecules could serve as targets for developing drugs.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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