Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2019639 | Prostaglandins & Other Lipid Mediators | 2012 | 5 Pages |
There is a sufficient body of work documenting the distribution of 3-hydroxy oxylipins in microbes. However, there is limited information on the role of these compounds in microbial pathogenesis. When derived from mammalian cells, these compounds regulate patho-biological processes, thus an understanding of 3-hydroxy oxylipin function and metabolism could prove important in shedding light on how these compounds mediate cellular pathology and physiology. This could present 3-hydroxy oxylipin biosynthetic pathways as targets for drug development. In this minireview, we interrogate the relevant yeast and bacterial 3-hydroxy oxylipin literature in order to appreciate how these compounds may influence the inflammatory response leading to disease development.
► This paper reviews the available literature on microbial 3-hydroxy oxylipins. ► These molecules are reported to mediate cellular pathology and physiology. ► Biosynthetic pathways of these molecules could serve as targets for developing drugs.