Article ID Journal Published Year Pages File Type
2019658 Prostaglandins & Other Lipid Mediators 2012 11 Pages PDF
Abstract
► Mice deficient in EP4 expression in smooth muscle (SMC) and endothelial cells. ► EP4 expression only in SMC is required for ductus arteriosus (DA) closure. ► Genome wide gene expression analysis of WT and EP4−/− DA. ► Identification of PGE2/EP4 dependent gene expression in the DA.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth
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