| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019685 | Prostaglandins & Other Lipid Mediators | 2010 | 6 Pages |
Abstract
ⶠSerine palmitoyltransferase (SPT) is a key enzyme in de novo sphingolipid biosynthesis. ⶠPartial hepatectomy and liver regeneration stimulates SPT activity. ⶠPPARα activation decreases protein expression and activity of SPT in regenerating rat liver. ⶠPlasma NEFA and liver sphinganine content decreased in the groups treated with PPARα agonist. ⶠPPARα activation inhibits de novo sphingolipid synthesis by decreasing availability of fatty acids.
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Authors
Piotr Zabielski, Agnieszka Blachnio-Zabielska, Marcin Baranowski, Malgorzata Zendzian-Piotrowska, Jan Gorski,