| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019692 | Prostaglandins & Other Lipid Mediators | 2011 | 7 Pages |
Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E2 in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, survival and self-renewal. We also describe a role for cannabinoids in hematopoiesis. Lastly, we discuss the yin and yang of various eicosanoids in modulating hematopoietic stem and progenitor cell functions and summarize potential strategies to take advantage of these effects for therapeutic benefit for hematopoietic stem cell transplantation.
• Prostaglandin E2 has both inhibitory and stimulatory regulation of hematopoiesis. • Short term pulse exposure of hematopoietic stem cells to dmPGE2 enhances their homing, survival and proliferation. • Eicosanoid based therapies represent an exciting clinical translation strategy to improve hematopoietic transplantation.
