| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019699 | Prostaglandins & Other Lipid Mediators | 2011 | 9 Pages |
Abstract
â This review discusses the role of 20-HETE in androgen-induced hypertension. â 20-HETE is the cytochrome P450-derived Ï-hydroxylated metabolite of arachidonic acid. â 20-HETE promotes vasoconstriction and endothelial dysfunction. â 20-HETE activates the RAS via induction of endothelial ACE. â CYP4F2 polymorphism is associated with increased urinary 20-HETE and hypertension.
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Authors
Cheng-Chia Wu, Michal Laniado Schwartzman,