Article ID Journal Published Year Pages File Type
2019773 Prostaglandins & Other Lipid Mediators 2012 6 Pages PDF
Abstract
► The effect of TNF on COX-2 expression was determined in the renal OM. ► An elevation in urinary TNF was seen in WT mice given a vitamin D analog (DHT). ► An increase in urinary PGE2 was observed in WT mice treated with DHT. ► COX-2 expression in the OM was elevated in WT but not TNF−/− mice given DHT. ► We demonstrated that during hypercalcemia COX-2 expression in the renal OM is TNF-dependent.
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