| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019790 | Prostaglandins & Other Lipid Mediators | 2008 | 8 Pages |
Abstract
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.
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Authors
Raymond L. Konger, Gopal K. Marathe, Yongxue Yao, Qiwei Zhang, Jeffrey B. Travers,