| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2020098 | Prostaglandins & Other Lipid Mediators | 2007 | 8 Pages |
Abstract
The temporal association between loss of function of the tumor suppressor adenomatous polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has been demonstrated in vivo and has led to the hypothesis that APC regulates COX-2 expression. This could potentially occur through a variety of mechanisms including the well-characterized ability of APC to negatively regulate Wnt signaling and decrease expression of target genes. However, recent findings suggest that the products of COX-2 elicit effects that occur upstream of the β-catenin/TCF/LEF pathway. This review will focus on the regulation of COX-2 by APC and the interplay between COX-2 and the Wnt signaling pathway.
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Authors
Annie L. Eisinger, Stephen M. Prescott, David A. Jones, Diana M. Stafforini,