Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2022642 | Regulatory Peptides | 2010 | 9 Pages |
Abstract
Mounting evidence shows that CgA is a marker of cardiovascular dysfunctions (essential hypertension, hypertrophic and dilatative cardiomyopathy, heart failure) and precursor of the cardioactive peptides vasostatin-1 (VS-1) and catestatin (Cts). This review focuses on recent knowledge regarding the myocardial, coronary and anti-adrenergic actions of VS-1. In particular, the negative inotropism, lusitropism and coronary dilation effects of rat CgA1-64 (rCgA) and human recombinant STACgA1-78 (hrSTACgA1-78) are summarized with attention on their counteracting isoproterenol- and endothelin-1-induced positive inotropism, as well as ET-1-dependent coronary constriction. The interactions between vasostatins (VSs), NPs and CA receptors are proposed as a paradigm of the heart capacity to organize complex connection-integration processes for maintaining homeostasis under intense cardio-excitatory stimuli (myocardial stress).
Keywords
LVEDPCNPBNPPKGPDE5SGCLVPPDE4rPPPDE2PGCPLBPDEsPDE3PDE1VNPVS-1ET-1CTSANPCASpKaCGARASeNOSNPsVSsadrenalineendothelin 1ISOisoproterenolSarcoplasmic reticulumBovine aortic endothelial cellsendothelial nitric oxide synthaseRenin–angiotensin systemSoluble guanylate cyclaseHeart ratePhosphodiesterasesphospholambanleft ventricular pressureHypothalamus-pituitary-adrenal axisRate pressure productHPAMyocardiumnoradrenalineNitric oxideprotein kinase Aprotein kinase GC-type natriuretic peptideB-type natriuretic peptidenatriuretic peptidesAtrial natriuretic peptidesParticulate guanylate cyclasecatecholaminesChromogranin ACoronariescatestatin
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Authors
Rosa Mazza, Sandra Imbrogno, Bruno Tota,